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SMAD2 and RUNX2
Number of citations of the paper that reports this interaction (PubMedID
10531362
)
80
Data Source:
HPRD
(in vitro)
SMAD2
RUNX2
Description
SMAD family member 2
RUNX family transcription factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytosol
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Transcription Factor Binding
Phosphatase Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Type I Transforming Growth Factor Beta Receptor Binding
Enhancer Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Primary MiRNA Binding
Disordered Domain Specific Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
ATP Binding
Protein Domain Specific Binding
BHLH Transcription Factor Binding
Repressing Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Negative Regulation Of Cell Proliferation
Response To Glucose
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Insulin Secretion
Lung Development
Adrenal Gland Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Wound Healing
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Binding
Pericardium Development
SMAD Protein Signal Transduction
Secondary Palate Development
Response To Cholesterol
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Ossification
Osteoblast Differentiation
Endochondral Ossification
Osteoblast Fate Commitment
Chondrocyte Differentiation
Chondrocyte Development
Osteoblast Development
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Cell Proliferation
Hemopoiesis
Neuron Differentiation
T Cell Differentiation
BMP Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Embryonic Forelimb Morphogenesis
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Regulation Of Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Embryonic Cranial Skeleton Morphogenesis
Stem Cell Differentiation
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
Cleidocranial dysplasia
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Central corneal thickness (
29760442
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
facial morphology traits (multivariate analysis) (
27193062
)
Height (
25429064
18391951
)
Hip minimal joint space width (
27701424
)
Hip shape (DXA scan) (
30320955
)
Intraocular pressure (
29785010
30054594
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Osteoarthritis (hip) (
30374069
)
Periodontal microbiota (
22699663
)
Progressive supranuclear palsy (
30089514
)
Survival in pancreatic cancer (
28470677
)
Interacting Genes
209 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJC7
DOCK8
DVL1
DYNC1H1
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF8
ZNHIT6
38 interacting genes:
ALYREF
AR
AXIN1
CBFB
CCNB1
CDK1
CEBPB
DVL2
EP300
ETS1
FHL2
FOS
HDAC3
HDAC4
HDAC6
HDAC7
HIF1A
HIVEP3
JUN
KAT6B
LEF1
MAP3K4
MSX2
PRIM2
PRKCD
RB1
RBM14
SMAD2
SMAD3
SMAD6
SMURF2
SOX9
STUB1
TAF1A
UBTF
XRCC5
XRCC6
YAP1
Entrez ID
4087
860
HPRD ID
03221
02566
Ensembl ID
ENSG00000175387
ENSG00000124813
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
A0A0D9SEN7
Q13950
Q32MY8
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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