MCM4 and ESCO2

Number of citations of the paper that reports this interaction (PubMedID 30100344)
2

Data Source:
BioGRID (two hybrid)

		MCM4	ESCO2
Description		minichromosome maintenance complex component 4	establishment of sister chromatid cohesion N-acetyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex	Chromatin XY Body Nucleoplasm Chromosome Golgi Apparatus Chromocenter Cell Junction Nuclear Pericentric Heterochromatin Site Of Double-strand Break
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Acetyltransferase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Establishment of Sister Chromatid Cohesion
Drugs
Diseases			ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS		Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		26 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUPT16H TLX2	8 interacting genes: MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA SMC3
Entrez ID		4173	157570
HPRD ID		09094	18564
Ensembl ID		ENSG00000104738	ENSG00000171320
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q56NI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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