MCM4 and ORC3

Number of citations of the paper that reports this interaction (PubMedID 12614612)
24

Data Source:
BioGRID (two hybrid)

		MCM4	ORC3
Description		minichromosome maintenance complex component 4	origin recognition complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex	Nuclear Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Nuclear Body DNA Replication Preinitiation Complex
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication Neural Precursor Cell Proliferation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)	Obesity-related traits ( 23251661)
Interacting Genes		26 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUPT16H TLX2	20 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 DBF4 FBXO7 H3-4 H4-16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 TERF2 USP2
Entrez ID		4173	23595
HPRD ID		09094	05398
Ensembl ID		ENSG00000104738	ENSG00000135336
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q9UBD5
PDB IDs			5UJ8 5UJM
Enriched GO Terms of Interacting Partners?
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