CXCR2 and CXCL1

Number of citations of the paper that reports this interaction (PubMedID 8702798)
86

Data Source:
HPRD (in vivo)

		CXCR2	CXCL1
Description		C-X-C motif chemokine receptor 2	C-X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Signaling Receptor Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Neutrophil Degranulation Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Neutrophil Chemotaxis Leukocyte Chemotaxis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Neutrophil Degranulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Anxiety disorder ( 25390645) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)
Interacting Genes		21 interacting genes: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	9 interacting genes: ACKR1 CXCR1 CXCR2 ESR1 HIPK2 HRAS MMP9 PTEN XRCC3
Entrez ID		3579	2919
HPRD ID		00907	01119
Ensembl ID		ENSG00000180871	ENSG00000163739
Uniprot IDs		P25025 Q53PC4	P09341
PDB IDs		4Q3H 5TYT	1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?
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