CXCR2 and ST13

Number of citations of the paper that reports this interaction (PubMedID 11751889)
19

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo)

		CXCR2	ST13
Description		C-X-C motif chemokine receptor 2	ST13 Hsp70 interacting protein
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Protein Binding Protein Domain Specific Binding Hsp70 Protein Binding Protein Binding, Bridging Heat Shock Protein Binding DATP Binding Identical Protein Binding Protein-containing Complex Binding Protein Dimerization Activity Unfolded Protein Binding Chaperone Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Neutrophil Degranulation Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	Protein Folding Response To Bacterium Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Folding Negative Regulation Of Protein Refolding Protein-containing Complex Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Feeling nervous ( 29500382)
Interacting Genes		21 interacting genes: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13	18 interacting genes: ALB APOE ASF1A CD101 CDC42 CTRC CXCR2 F2 HSP90AA1 HSPA1A HSPA4 HSPA8 NOS3 OLFM2 PSEN1 SMAD2 TTR VAV2
Entrez ID		3579	6767
HPRD ID		00907	08426
Ensembl ID		ENSG00000180871	ENSG00000100380
Uniprot IDs		P25025 Q53PC4	A0A140VKA6 B4E0U6 P50502 Q0IJ56
PDB IDs		4Q3H 5TYT	1UZS
Enriched GO Terms of Interacting Partners?
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