LTBR and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 9626059)
15

Data Source:
HPRD (in vitro)

		LTBR	TRAF4
Description		lymphotoxin beta receptor	TNF receptor associated factor 4
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 27182965 28928442)
Interacting Genes		14 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	78 interacting genes: ALKBH4 BAHD1 BANP BCKDK BCL6B BEX3 BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FAM214B FAM90A1 FAT1 FBXL18 FTH1 GOLGA2 GORASP2 GPRASP1 HGS HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS1 RBPMS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2D1 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581 ZNF688
Entrez ID		4055	9618
HPRD ID		02988	03915
Ensembl ID		ENSG00000111321	ENSG00000076604
Uniprot IDs		P36941	A0A024QZ19 A0A024QZ59 Q9BUZ4
PDB IDs		1RF3 4MXW	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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