LTBP3 and PELI2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LTBP3	PELI2
Description		latent transforming growth factor beta binding protein 3	pellino E3 ubiquitin protein ligase family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome	Cytosol
	Molecular Function	Calcium Ion Binding Transforming Growth Factor Beta Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		Molecules associated with elastic fibres	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Acne (severe) ( 24927181) Heel bone mineral density ( 30598549) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		12 interacting genes: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3	19 interacting genes: BCL10 CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 TIMM9 TP53 UBQLN4
Entrez ID		4054	57161
HPRD ID		03649	17835
Ensembl ID		ENSG00000168056	ENSG00000139946
Uniprot IDs		B9EG76 Q8WYU6 Q9NS15	Q9H716 Q9HAT8
PDB IDs			3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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