KPNA7 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 18258596)
47

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		KPNA7	H1-2
Description		karyopherin subunit alpha 7	H1.2 linker histone, cluster member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Spindle Cytosol	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Blastocyst Development NLS-bearing Protein Import Into Nucleus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Modulation By Virus Of Host Process Positive Regulation Of Histone H3-K27 Trimethylation	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908) Lack of premeditation ( 30718321) Ulcerative colitis ( 28067908 20228798) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		2 interacting genes: H1-2 TWIST1	30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1
Entrez ID		402569	3006
HPRD ID		19598	07514
Ensembl ID		ENSG00000185467	ENSG00000187837
Uniprot IDs		A9QM74	P16403
PDB IDs
Enriched GO Terms of Interacting Partners?
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