LIMK2 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 8537403)
50

Data Source:
BioGRID (enzymatic study)

		LIMK2	H1-1
Description		LIM domain kinase 2	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network Mitotic Spindle	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Cell Surface Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Double-stranded DNA Binding Protein Binding Heparin Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Phosphorylation Actin Cytoskeleton Organization Astral Microtubule Organization Head Development Cornea Development In Camera-type Eye	Nucleosome Assembly Regulation Of Transcription, DNA-templated Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Paclitaxel-induced neuropathy ( 23776197) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1	50 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		3985	3024
HPRD ID		03585	00820
Ensembl ID		ENSG00000182541	ENSG00000124610
Uniprot IDs		A0A024R1H6 A0A024R1M2 P53671	Q02539
PDB IDs		1X6A 4TPT 5NXD
Enriched GO Terms of Interacting Partners?
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