LIMK2 and PARD3

Number of citations of the paper that reports this interaction (PubMedID 16505165)
29

Data Source:
HPRD (in vivo, in vitro)

		LIMK2	PARD3
Description		LIM domain kinase 2	par-3 family cell polarity regulator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network Mitotic Spindle	Cell Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Apical Junction Complex Axonal Growth Cone
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Phosphorylation Actin Cytoskeleton Organization Astral Microtubule Organization Head Development Cornea Development In Camera-type Eye	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Paclitaxel-induced neuropathy ( 23776197) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)	Acute lymphoblastic leukemia (childhood) ( 19684603) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Interacting Genes		12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1	28 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ
Entrez ID		3985	56288
HPRD ID		03585	05994
Ensembl ID		ENSG00000182541	ENSG00000148498
Uniprot IDs		A0A024R1H6 A0A024R1M2 P53671	Q8TEW0
PDB IDs		1X6A 4TPT 5NXD	2KOM
Enriched GO Terms of Interacting Partners?
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