H1-1 and TLK1

Number of citations of the paper that reports this interaction (PubMedID 10523312)
52

Data Source:
HPRD (in vitro)

		H1-1	TLK1
Description		H1.1 linker histone, cluster member	tousled like kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Cell Surface Vesicle	Nucleus Nucleoplasm
	Molecular Function	Double-stranded DNA Binding Protein Binding Heparin Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Nucleosome Assembly Regulation Of Transcription, DNA-templated Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 27863252)
Interacting Genes		50 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	15 interacting genes: ASF1A ASF1B AURKA CHEK1 H1-1 LUZP4 MBP NBN PTPN11 RAD9A SNAP23 TLK2 TPM3 UBE3C YWHAE
Entrez ID		3024	9874
HPRD ID		00820	12232
Ensembl ID		ENSG00000124610	ENSG00000198586
Uniprot IDs		Q02539	Q9UKI8
PDB IDs
Enriched GO Terms of Interacting Partners?
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