H1-1 and CCNA1

Number of citations of the paper that reports this interaction (PubMedID 9860976)
8

Data Source:
BioGRID (enzymatic study)

		H1-1	CCNA1
Description		H1.1 linker histone, cluster member	cyclin A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Cell Surface Vesicle	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Double-stranded DNA Binding Protein Binding Heparin Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Nucleosome Assembly Regulation Of Transcription, DNA-templated Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Male Meiosis I Spermatogenesis Protein Deubiquitination Mitotic Cell Cycle Phase Transition Cell Division
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS			Cocaine dependence ( 31212010) Nickel levels ( 26025379)
Interacting Genes		50 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	35 interacting genes: ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6
Entrez ID		3024	8900
HPRD ID		00820	04946
Ensembl ID		ENSG00000124610	ENSG00000133101
Uniprot IDs		Q02539	A0A140VJG0 P78396
PDB IDs
Enriched GO Terms of Interacting Partners?
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