LAMC1 and NID2

Number of citations of the paper that reports this interaction (PubMedID 9733643)
69

Data Source:
HPRD (in vitro)

		LAMC1	NID2
Description		laminin subunit gamma 1	nidogen 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly	Cell Adhesion Cell-matrix Adhesion Extracellular Matrix Organization Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Laminin interactions Laminin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) Height ( 31562340) Hypertriglyceridemia ( 27599772) Systemic lupus erythematosus ( 24871463)	Blood protein levels ( 30072576 29875488) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Lung cancer (smoking interaction) ( 24658283) Pulmonary function ( 17903307) Triglyceride levels ( 29403010) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3	8 interacting genes: COL13A1 COL1A1 COL4A1 ELN HSPG2 KRTAP10-3 LAMC1 SKIL
Entrez ID		3915	22795
HPRD ID		01030	05654
Ensembl ID		ENSG00000135862	ENSG00000087303
Uniprot IDs		P11047 Q6NVY8	Q14112
PDB IDs		5XAU
Enriched GO Terms of Interacting Partners?
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