LAMC1 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 11683410)
124

Data Source:
BioGRID (pull down)

		LAMC1	ANTXR2
Description		laminin subunit gamma 1	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly	Reproductive Process Toxin Transport
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) Height ( 31562340) Hypertriglyceridemia ( 27599772) Systemic lupus erythematosus ( 24871463)	Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Hand grip strength ( 29691431) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3	10 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		3915	118429
HPRD ID		01030	07452
Ensembl ID		ENSG00000135862	ENSG00000163297
Uniprot IDs		P11047 Q6NVY8	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5XAU	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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