NID2 and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 9733643)
69

Data Source:
HPRD (in vitro)

		NID2	HSPG2
Description		nidogen 2	heparan sulfate proteoglycan 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Extracellular Matrix Organization Basement Membrane Organization	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Cardiovascular System Development
Pathways		Laminin interactions Laminin interactions	Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation
Drugs			Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Lung cancer (smoking interaction) ( 24658283) Pulmonary function ( 17903307) Triglyceride levels ( 29403010) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Atrial fibrillation ( 30061737) Height ( 28552196)
Interacting Genes		8 interacting genes: COL13A1 COL1A1 COL4A1 ELN HSPG2 KRTAP10-3 LAMC1 SKIL	31 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR UBC VWA1
Entrez ID		22795	3339
HPRD ID		05654	00804
Ensembl ID		ENSG00000087303	ENSG00000142798
Uniprot IDs		Q14112	P98160
PDB IDs			3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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