RHOC and CIT

Number of citations of the paper that reports this interaction (PubMedID 8543060)
56

Data Source:
HPRD (two hybrid, in vitro)

		RHOC	CIT
Description		ras homolog family member C	citron rho-interacting serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Division Site Cleavage Furrow Stereocilium Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Cleavage Furrow
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Scaffold Protein Binding
	Biological Process	Mitotic Cytokinesis Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process
Pathways		Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins	RHO GTPases activate CIT RHO GTPases activate CIT
Drugs
Diseases
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372)	Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		7 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 ROCK1 RTKN	16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		389	11113
HPRD ID		01322	09289
Ensembl ID		ENSG00000155366	ENSG00000122966
Uniprot IDs		A0A024R0C8 P08134	O14578
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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