KARS1 and FRS3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		KARS1	FRS3
Description		lysyl-tRNA synthetase 1	fibroblast growth factor receptor substrate 3
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GO Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Plasma Membrane
	Molecular Function	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
Drugs		L-Lysine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Menarche (age at onset) ( 25231870)
Interacting Genes		16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM	28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP
Entrez ID		3735	10817
HPRD ID		03249	06373
Ensembl ID		ENSG00000065427	ENSG00000137218
Uniprot IDs		Q15046	A0A140VJJ7 O43559
PDB IDs		3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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