KARS1 and DARS2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, two hybrid)

		KARS1	DARS2
Description		lysyl-tRNA synthetase 1	aspartyl-tRNA synthetase 2, mitochondrial
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GO Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Mitochondrial tRNA aminoacylation
Drugs		L-Lysine	L-Aspartic Acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS			Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM	4 interacting genes: AIMP2 DPYSL5 EPHA8 KARS1
Entrez ID		3735	55157
HPRD ID		03249	07677
Ensembl ID		ENSG00000065427	ENSG00000117593
Uniprot IDs		Q15046	Q6PI48 Q9H9J7
PDB IDs		3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH	4AH6
Enriched GO Terms of Interacting Partners?
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