PIK3R3 and ABCB6

Number of citations of the paper that reports this interaction (PubMedID 18624398)
14

Data Source:
BioGRID (two hybrid)

		PIK3R3	ABCB6
Description		phosphoinositide-3-kinase regulatory subunit 3	ATP binding cassette subfamily B member 6 (Langereis blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Golgi Membrane Cell Nucleoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endosome Vacuolar Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane ATP-binding Cassette (ABC) Transporter Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity	ATP Binding Heme-transporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Heme Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Positive Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation	Porphyrin-containing Compound Biosynthetic Process Cellular Iron Ion Homeostasis Brain Development Heme Transport Heme Transmembrane Transport Skin Development Transmembrane Transport
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL	Mitochondrial ABC transporters Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)
Drugs		Isoprenaline SF1126
Diseases
GWAS		Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Breast cancer ( 29059683) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Sodium levels ( 29403010) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		81 interacting genes: ABCB6 ABL2 AMBP ANKS1A AUNIP AXL BRK1 BTK CAMK1 CCDC14 CCDC33 CEP126 CEP19 CLNK CRBN CRK DARS1 DCAF8 DRAP1 DSN1 E2F6 EGFR ERBB2 ERBB3 ESR1 FBN3 FER FGB FOXO1 FSD2 FYN GC HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 KARS1 KHDRBS1 KLC2 KLF15 KMT2B L3MBTL3 LNX2 LUC7L2 MBIP MECOM MICAL1 MTF2 NCK1 ORM1 PACRGL PCDHB5 PDGFRB PELO PIK3CA PLB1 PPARA PSME1 QARS1 RB1 RING1 SERF1A SOCS6 SRC STAT3 TEC TERF2 TNNC2 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 ZMAT1 ZNF281 ZNF451	1 interacting genes: PIK3R3
Entrez ID		8503	10058
HPRD ID		05831	09261
Ensembl ID		ENSG00000117461	ENSG00000115657
Uniprot IDs		B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569	Q9NP58
PDB IDs			3NH6 3NH9 3NHA 3NHB
Enriched GO Terms of Interacting Partners?
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