HTR2B and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 11916537)
110

Data Source:
HPRD (in vivo)

		HTR2B	GNAQ
Description		5-hydroxytryptamine receptor 2B	G protein subunit alpha q
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Synapse	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Serotonin Binding	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus G Protein-coupled Serotonin Receptor Signaling Pathway	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway
Pathways		Serotonin receptors G alpha (q) signalling events	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Olanzapine Methylergometrine Mirtazapine Pramipexole Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Minaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic Acid Diethylamide OPC-28326 Epicept NP-1 Cariprazine Mianserin Asenapine Esmirtazapine Setiptiline Tiapride
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Bipolar disorder ( 31043756)
Interacting Genes		4 interacting genes: GNA11 GNAQ LNX1 SNTA1	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		3357	2776
HPRD ID		03077	02998
Ensembl ID		ENSG00000135914	ENSG00000156052
Uniprot IDs		P41595	A0A024R240 P50148
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0
Enriched GO Terms of Interacting Partners?
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