HTR2B and GNA11

Number of citations of the paper that reports this interaction (PubMedID 11916537)
110

Data Source:
HPRD (in vivo)

		HTR2B	GNA11
Description		5-hydroxytryptamine receptor 2B	G protein subunit alpha 11
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Synapse	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Serotonin Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus G Protein-coupled Serotonin Receptor Signaling Pathway	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH
Pathways		Serotonin receptors G alpha (q) signalling events	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Olanzapine Methylergometrine Mirtazapine Pramipexole Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Minaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic Acid Diethylamide OPC-28326 Epicept NP-1 Cariprazine Mianserin Asenapine Esmirtazapine Setiptiline Tiapride
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: GNA11 GNAQ LNX1 SNTA1	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR
Entrez ID		3357	2767
HPRD ID		03077	00759
Ensembl ID		ENSG00000135914	ENSG00000088256
Uniprot IDs		P41595	P29992
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0	6OIJ
Enriched GO Terms of Interacting Partners?
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