GNAQ and S1PR2

Number of citations of the paper that reports this interaction (PubMedID 10488065)
76

Data Source:
HPRD (in vitro)

		GNAQ	S1PR2
Description		G protein subunit alpha q	sphingosine-1-phosphate receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway	Activation Of MAPK Activity Sphingosine-1-phosphate Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Actin Cytoskeleton Reorganization Filopodium Assembly Negative Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Alanine transaminase levels ( 29403010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 30578418)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	3 interacting genes: GNA13 GNAI1 GNAQ
Entrez ID		2776	9294
HPRD ID		02998	05488
Ensembl ID		ENSG00000156052	ENSG00000267534
Uniprot IDs		A0A024R240 P50148	A0A024R7B2 O95136
PDB IDs			1ZTI
Enriched GO Terms of Interacting Partners?
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