HPD and HIVEP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HPD	HIVEP1
Description		4-hydroxyphenylpyruvate dioxygenase	HIVEP zinc finger 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Extracellular Exosome	Nucleus Nucleoplasm Mitochondrion Nuclear Body
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Tyrosine catabolism
Drugs		Nitisinone (1-Tert-Butyl-5-Hydroxy-1h-Pyrazol-4-Yl)-(6-Methanesulfonyl-4'-Methoxy-2-Methyl-Biphenyl-3-Yl)-Methanone
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Obesity-related traits ( 23251661) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414)	Alcohol and nicotine co-dependence ( 22488850) Body mass index ( 28892062 25673413 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Takayasu arteritis ( 25604533)
Interacting Genes		4 interacting genes: CDKN1A HIVEP1 IKBKG RIDA	37 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BHLHE40 BNIP3 BRCA1 CACNA1A CLK1 DNAJA1 EMG1 GAA GSDMB HPD HSPA1A IMMT MAGED1 MAPK14 MAPK8 MTMR3 NHLH1 NINJ1 NUCB1 PRKAR1A RAB1A RIDA SDCBP SERTAD1 SMAD3 SNX4 SOCS3 SOX10 SRPK2 STAT3 TMEM176A
Entrez ID		3242	3096
HPRD ID		02041	01925
Ensembl ID		ENSG00000158104	ENSG00000095951
Uniprot IDs		P32754	P15822
PDB IDs		3ISQ 5EC3	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?
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