EN2 and FOXA2

Number of citations of the paper that reports this interaction (PubMedID 12642491)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EN2	FOXA2
Description		engrailed homeobox 2	forkhead box A2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Membrane RSC-type Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Embryonic Brain Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways			Regulation of gene expression in beta cells
Drugs		N-Cyclohexyltaurine
Diseases
GWAS		Metabolite levels ( 23823483)	Adolescent idiopathic scoliosis ( 25784220) Birth weight ( 31043758) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458) Vitamin D levels ( 26704534)
Interacting Genes		1 interacting genes: FOXA2	9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		2020	3170
HPRD ID		08836	02618
Ensembl ID		ENSG00000164778	ENSG00000125798
Uniprot IDs		P19622	B0ZTD4 Q9Y261
PDB IDs			5X07
Enriched GO Terms of Interacting Partners?
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