SERTAD1 and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SERTAD1	EGLN3
Description		SERTA domain containing 1	egl-9 family hypoxia inducible factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways			Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		39 interacting genes: ADCY1 ASB8 ATXN7L3 CCND2 CDK4 CDKN2A CHURC1 CIB3 COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAH HIVEP1 HSPB1 KAT2B KLHL42 MVP NEDD4 P4HA3 PATE1 POT1 PRDM4 RBX1 RCHY1 ROPN1 SETD7 SFI1 SMAD3 SPEN STAT5B SUPT7L TGM2 TLR4 TRIM28 XIAP ZNF410	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		29950	112399
HPRD ID		15326	06972
Ensembl ID		ENSG00000197019	ENSG00000129521
Uniprot IDs		Q53GC0 Q9UHV2	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs
Enriched GO Terms of Interacting Partners?
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