SERTAD1 and SPEN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SERTAD1	SPEN
Description		SERTA domain containing 1	spen family transcriptional repressor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Transcriptional Repressor Complex Extracellular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis
Pathways
Drugs
Diseases
GWAS		Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591)
Interacting Genes		39 interacting genes: ADCY1 ASB8 ATXN7L3 CCND2 CDK4 CDKN2A CHURC1 CIB3 COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAH HIVEP1 HSPB1 KAT2B KLHL42 MVP NEDD4 P4HA3 PATE1 POT1 PRDM4 RBX1 RCHY1 ROPN1 SETD7 SFI1 SMAD3 SPEN STAT5B SUPT7L TGM2 TLR4 TRIM28 XIAP ZNF410	22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		29950	23013
HPRD ID		15326	10230
Ensembl ID		ENSG00000197019	ENSG00000065526
Uniprot IDs		Q53GC0 Q9UHV2	Q96T58
PDB IDs			1OW1 2RT5 4P6Q
Enriched GO Terms of Interacting Partners?
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