EGLN3 and NCAPH2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EGLN3	NCAPH2
Description		egl-9 family hypoxia inducible factor 3	non-SMC condensin II complex subunit H2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Membrane Cell Junction Intercellular Bridge
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Chromatin Binding Protein Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Mitotic Chromosome Condensation Meiotic Chromosome Condensation T Cell Differentiation In Thymus Chromosome Organization Mitotic Sister Chromatid Separation Female Meiosis Chromosome Separation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Condensation of Prophase Chromosomes
Drugs		Vitamin C Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cerebrospinal fluid clusterin levels ( 26545630) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 20139978) Red blood cell traits ( 23222517)
Interacting Genes		25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83	11 interacting genes: ACTN2 EGLN3 FOLR1 LMO2 PRPF31 SNRPC TRAF2 TTC25 TTC32 TUBB USHBP1
Entrez ID		112399	29781
HPRD ID		06972	11783
Ensembl ID		ENSG00000129521	ENSG00000025770
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q6IBW4
PDB IDs
Enriched GO Terms of Interacting Partners?
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