GPS2 and CNOT2

Number of citations of the paper that reports this interaction (PubMedID 16712523)
13

Data Source:
BioGRID (two hybrid)

		GPS2	CNOT2
Description		G protein pathway suppressor 2	CCR4-NOT transcription complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369)
Interacting Genes		24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53	8 interacting genes: CNOT1 CNOT3 CNOT4 CNOT8 DDB1 GPS2 NCOR1 NCOR2
Entrez ID		2874	4848
HPRD ID		11878	05367
Ensembl ID		ENSG00000132522	ENSG00000111596
Uniprot IDs		Q13227	A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs		2L5G	4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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