GPS2 and C19orf57

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GPS2	C19orf57
Description		G protein pathway suppressor 2	chromosome 19 open reading frame 57
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex	Cellular_component
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	Multicellular Organism Development
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53	27 interacting genes: AIMP2 AKAP8L APP C19orf25 CENPQ COPS4 CTNNAL1 EWSR1 FAM9B FBXO25 GDF15 GPS2 HAUS3 HOMER1 IKBKG KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 PSMA6 RABL6 RUNX1T1 STXBP1 TRIM23 TSC22D3 VCL
Entrez ID		2874	79173
HPRD ID		11878	14415
Ensembl ID		ENSG00000132522	ENSG00000132016
Uniprot IDs		Q13227	Q0VDD7
PDB IDs		2L5G
Enriched GO Terms of Interacting Partners?
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