GPS2 and SESTD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GPS2	SESTD1
Description		G protein pathway suppressor 2	SEC14 and spectrin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex	Calcium Channel Complex Intermediate Filament Cytoskeleton
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Phosphatidylserine Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylcholine Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS			Late-onset Alzheimer's disease ( 27770636) Objective response to lithium treatment ( 26503763) Optic disc size ( 31809533) Presence of antiphospholipid antibodies ( 23509613) Serum uric acid levels ( 29559957)
Interacting Genes		24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53	2 interacting genes: GPS2 STMN1
Entrez ID		2874	91404
HPRD ID		11878	11549
Ensembl ID		ENSG00000132522	ENSG00000187231
Uniprot IDs		Q13227	B3KTX3 Q86VW0
PDB IDs		2L5G
Enriched GO Terms of Interacting Partners?
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