CNOT2 and DDB1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		CNOT2	DDB1
Description		CCR4-NOT transcription complex subunit 2	damage specific DNA binding protein 1
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Nuclear Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	DNA Binding Damaged DNA Binding Protein Binding Protein Binding, Bridging Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Viral Process Wnt Signaling Pathway Protein Ubiquitination Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Regulation Of Circadian Rhythm DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Interaction With Symbiont Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369)
Interacting Genes		8 interacting genes: CNOT1 CNOT3 CNOT4 CNOT8 DDB1 GPS2 NCOR1 NCOR2	48 interacting genes: ABL1 BRAP CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 GPS1 GSPT1 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MAFB MEF2A MUS81 PHIP PIN1 PTEN RASSF1 RBBP7 SALL2 SIN3A SIRT7 SKP2 STAT1 SUPT3H SUV39H1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZNF277
Entrez ID		4848	1642
HPRD ID		05367	10952
Ensembl ID		ENSG00000111596	ENSG00000167986
Uniprot IDs		A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	Q16531
PDB IDs		4C0D 4C0F 5FU6 5FU7	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92
Enriched GO Terms of Interacting Partners?
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