GRK4 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vivo, in vitro)

		GRK4	BDKRB2
Description		G protein-coupled receptor kinase 4	bradykinin receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		6 interacting genes: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4	12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		2868	624
HPRD ID		00656	00213
Ensembl ID		ENSG00000125388	ENSG00000168398
Uniprot IDs		P32298	P30411
PDB IDs		4YHJ
Enriched GO Terms of Interacting Partners?
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