GRK4 and FSHR

Number of citations of the paper that reports this interaction (PubMedID 10379886)
17

Data Source:
HPRD (in vitro)

		GRK4	FSHR
Description		G protein-coupled receptor kinase 4	follicle stimulating hormone receptor
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GO Annotations	Cellular Component	Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways			Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin
Diseases			Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Ovarian hyperstimulation syndrome (OHSS)
GWAS		Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		6 interacting genes: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4	20 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		2868	2492
HPRD ID		00656	00639
Ensembl ID		ENSG00000125388	ENSG00000170820
Uniprot IDs		P32298	A0A1D5RMN4 P23945
PDB IDs		4YHJ	1XUN 1XWD 4AY9 4MQW
Enriched GO Terms of Interacting Partners?
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