MTREX and PBX2

Number of citations of the paper that reports this interaction (PubMedID 14667819)
35

Data Source:
HPRD (two hybrid)

		MTREX	PBX2
Description		Mtr4 exosome RNA helicase	PBX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Transcription Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process SnRNA Catabolic Process	Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Crohn's disease ( 23266558) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1 ZCCHC8	22 interacting genes: BAIAP2 BLOC1S1 CARD9 CCDC88B CENPBD1 COPS6 DCTN3 ELP1 HOXA1 HOXA9 HOXB8 MCRS1 MTREX NEU1 NUP62 PBX1 PKNOX1 RPL4 RPS6KC1 SMYD3 UBE2E1 ZDHHC7
Entrez ID		23517	5089
HPRD ID		13777	08890
Ensembl ID		ENSG00000039123	ENSG00000204304
Uniprot IDs		P42285 Q3MHC9	A0A024RCR3 P40425
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1
Enriched GO Terms of Interacting Partners?
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