KLK5 and TGFB1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		KLK5	TGFB1
Description		kallikrein related peptidase 5	transforming growth factor beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity	Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cornification Amelogenesis	MAPK Cascade Vasculogenesis Epithelial To Mesenchymal Transition Neural Tube Closure Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Platelet Degranulation Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Inflammatory Response Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Neural Tube Development Negative Regulation Of Cell-cell Adhesion Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Complex Assembly Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Vascular Permeability Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Cell-cell Junction Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Negative Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Remodeling Pathway-restricted SMAD Protein Phosphorylation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Negative Regulation Of Gene Silencing By MiRNA Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Organic Cyclic Compound Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development Embryonic Liver Development Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Formation of the cornified envelope Formation of the cornified envelope	Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF
Drugs			Hyaluronidase Hyaluronidase (Human Recombinant)
Diseases			Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS			Blood protein levels ( 30072576) Colorectal cancer ( 27145994 24836286) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)
Interacting Genes		11 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R NOTCH2 SERPINA1 TGFB1 TSG101	59 interacting genes: ACVRL1 AGR3 ANGPTL4 APP BCAS3 BGN BLID BMP2 BMP3 CCDC33 CCL3 CCL5 CCN2 COL2A1 CST6 DAXX DCN DIRAS3 DPT EIF3I ENG FCN1 FKBP1A FMOD FNTA GREB1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 LAMTOR5 LTBP1 LTBP3 LTBP4 MEOX2 MMP2 MTA3 NSD3 PDLIM2 PRSS50 PSMC3IP PZP SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP VASN VTN YWHAE
Entrez ID		25818	7040
HPRD ID		05732	01821
Ensembl ID		ENSG00000167754	ENSG00000105329
Uniprot IDs		Q9Y337	A0A499FJK2 P01137
PDB IDs		2PSX 2PSY 6QFE	1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP
Enriched GO Terms of Interacting Partners?
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