KLK5 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		KLK5	BAG4
Description		kallikrein related peptidase 5	BAG cochaperone 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Nucleus Cytosol Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cornification Amelogenesis	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Pathways		Formation of the cornified envelope Formation of the cornified envelope	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		11 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R NOTCH2 SERPINA1 TGFB1 TSG101	38 interacting genes: APOBEC1 ATAD2 BAP1 BCAS3 BCL2 BEX1 CASZ1 CCL5 DIRAS3 EPSTI1 ERRFI1 GLCE GRAP2 HSPA1A HSPA8 IL13RA2 IL24 ITIH5 KLK5 KLK7 KLK9 LRATD2 LYPD3 MRC2 MTA3 NAT2 PDLIM2 PLAT PRDM14 RASL10B RHOBTB2 RNF20 RPL22 SCGB3A1 TBC1D7 THRSP TNFRSF1A TNFRSF25
Entrez ID		25818	9530
HPRD ID		05732	04861
Ensembl ID		ENSG00000167754	ENSG00000156735
Uniprot IDs		Q9Y337	O95429
PDB IDs		2PSX 2PSY 6QFE	1M62 1M7K
Enriched GO Terms of Interacting Partners?
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