TNFAIP8 and MED4

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		TNFAIP8	MED4
Description		TNF alpha induced protein 8	mediator complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways		PI Metabolism	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31619474) HDL cholesterol ( 30275531) Heschl's gyrus morphology ( 25130324) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglycerides ( 30275531) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 28552196 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		6 interacting genes: INO80E MED4 PLEKHF2 PRR13 SDCBP TIFA	33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		25816	29079
HPRD ID		18204	16145
Ensembl ID		ENSG00000145779	ENSG00000136146
Uniprot IDs		B3KUI2 O95379	A0A024RDY7 Q9NPJ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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