LDOC1 and LATS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LDOC1	LATS1
Description		LDOC1 regulator of NFKB signaling	large tumor suppressor kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Spindle Pole Microtubule Organizing Center Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding
	Biological Process	Maternal Placenta Development Negative Regulation Of Cell Proliferation Maternal Process Involved In Parturition Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Regulation Of Growth Hormone Activity	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS			Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)
Interacting Genes		68 interacting genes: AATF ABLIM1 AEBP2 AP1M1 ATF4 ATP6V1G1 BARD1 C1orf109 CCDC33 CCDC85B CEBPE CTNNBL1 DPF2 DPPA4 FAM107A FAM193B FAM50B FAM90A1 FOSL1 FXR2 GNL3L HAUS1 HDAC4 HGS IKZF3 IKZF5 INPP1 KRT15 KRT18 LATS1 LENG1 LNX1 MEAF6 MFAP1 MYC MZF1 NOD2 NRIP1 NXF1 PEG10 PLEKHF2 POLL PRPF31 PSMA1 PSMF1 RAB29 RNF6 SDCBP SETD5 SH2D4A SMARCB1 SMARCD1 TASOR2 TBC1D7 TLE5 TMSB4XP1 TNNT1 TTC23 UTP14A WT1 ZBTB16 ZBTB24 ZGPAT ZNF250 ZNF408 ZNF564 ZNF688 ZNF774	45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX
Entrez ID		23641	9113
HPRD ID		02322	09147
Ensembl ID		ENSG00000182195	ENSG00000131023
Uniprot IDs		O95751	O95835
PDB IDs			4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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