CD2AP and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 12530983)
50

Data Source:
HPRD (in vivo, in vitro)

		CD2AP	PSTPIP1
Description		CD2 associated protein	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Fibrillar Center Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Actin Cytoskeleton Endocytic Vesicle Filamentous Actin Perinuclear Region Of Cytoplasm Extracellular Exosome	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Protein C-terminus Binding SH3 Domain Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Cell Cycle Signal Transduction Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta1 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Secretion Negative Regulation Of Small GTPase Mediated Signal Transduction Cell Division Protein-containing Complex Assembly Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		Nephrin family interactions	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Neurofibrillary tangles ( 31497858)
Interacting Genes		33 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688
Entrez ID		23607	9051
HPRD ID		05026	05891
Ensembl ID		ENSG00000198087	ENSG00000140368
Uniprot IDs		Q9Y5K6	A0A0S2Z5P3 O43586
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V	2DIL
Enriched GO Terms of Interacting Partners?
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