PDZD2 and CST3

Number of citations of the paper that reports this interaction (PubMedID 1731767)
17

Data Source:
HPRD (in vitro)

		PDZD2	CST3
Description		PDZ domain containing 2	cystatin C
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cell-cell Junction	Extracellular Region Basement Membrane Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Axon Nuclear Membrane Neuronal Cell Body Contractile Fiber Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function		Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Cell Adhesion	Eye Development Response To Hypoxia Apoptotic Process Defense Response Brain Development Salivary Gland Development Embryo Implantation Positive Regulation Of Cell Proliferation Response To Carbohydrate Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Response To Nutrient Levels Response To Estradiol Regulation Of Tissue Remodeling Circadian Sleep/wake Cycle, REM Sleep Regulation Of Programmed Cell Death Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Proteolysis Response To Axon Injury Sertoli Cell Development Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Supramolecular Fiber Organization
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Height ( 28552196) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Working memory ( 31598132)	Blood protein levels ( 30072576 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4	9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
Entrez ID		23037	1471
HPRD ID		10142	05056
Ensembl ID		ENSG00000133401	ENSG00000101439
Uniprot IDs		A0A024RE15 O15018	A0A0K0K1J1 P01034
PDB IDs			1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
Enriched GO Terms of Interacting Partners?
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