MAPKBP1 and TCF12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAPKBP1	TCF12
Description		mitogen-activated protein kinase binding protein 1	transcription factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitotic Spindle Pole	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding CAMP Response Element Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Bacterium Negative Regulation Of Interleukin-8 Secretion	Regulation Of Transcription By RNA Polymerase II Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Urinary albumin excretion ( 30220432) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252) Type 2 diabetes ( 30297969)
Interacting Genes		31 interacting genes: ADAMTSL4 ALG13 APTX GLRX3 KEAP1 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP5-9 KRTAP9-2 KRTAP9-4 MAPK10 MAPK8 MAPK9 MDFI MEOX2 NOTCH2NLA RGS20 SIAH1 SPRY2 TCF12 TCF4 TEX11 TRIM27 TRIP6	59 interacting genes: ACTB ADAM10 ARMC8 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CRCP CREBBP DGCR6 EDRF1 EP300 FRMD6 HAND1 HOPX ID1 ID2 ID3 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MYF6 NAGK OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS1 RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 YKT6 ZNF688
Entrez ID		23005	6938
HPRD ID		17465	02725
Ensembl ID		ENSG00000137802	ENSG00000140262
Uniprot IDs		O60336	A0A024R5T1 A0A024R5Z0 F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?
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