MAPKBP1 and SIAH1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAPKBP1	SIAH1
Description		mitogen-activated protein kinase binding protein 1	siah E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitotic Spindle Pole	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Bacterium Negative Regulation Of Interleukin-8 Secretion	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Neuron Apoptotic Process Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Urinary albumin excretion ( 30220432) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Height ( 28552196) Waist circumference ( 28552196)
Interacting Genes		31 interacting genes: ADAMTSL4 ALG13 APTX GLRX3 KEAP1 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP5-9 KRTAP9-2 KRTAP9-4 MAPK10 MAPK8 MAPK9 MDFI MEOX2 NOTCH2NLA RGS20 SIAH1 SPRY2 TCF12 TCF4 TEX11 TRIM27 TRIP6	141 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 BAG1 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4-16 HIF1AN HIPK2 HIPK3 INHA IQCN KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LMNA MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NANOS2 NANOS3 NECTIN2 NELFA NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SH3RF1 SLC9A3R2 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX
Entrez ID		23005	6477
HPRD ID		17465	03736
Ensembl ID		ENSG00000137802	ENSG00000196470
Uniprot IDs		O60336	Q8IUQ4
PDB IDs			2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ
Enriched GO Terms of Interacting Partners?
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