RIMS1 and STX1A

Number of citations of the paper that reports this interaction (PubMedID 11438522)
9

Data Source:
HPRD (in vitro)

		RIMS1	STX1A
Description		regulating synaptic membrane exocytosis 1	syntaxin 1A
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Cell Junction Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Presynaptic Membrane Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	RNA Binding Protein Binding Rab GTPase Binding GTPase Regulator Activity Ion Channel Binding Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion Regulated Exocytosis Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium Ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		15 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	60 interacting genes: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEC22B SEPTIN2 SEPTIN5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18
Entrez ID		22999	6804
HPRD ID		09435	01721
Ensembl ID		ENSG00000079841	ENSG00000106089
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	Q16623 Q75ME0
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?
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