STX1A and CACNA1D

Number of citations of the paper that reports this interaction (PubMedID 10468580)
39

Data Source:
HPRD (in vivo)

		STX1A	CACNA1D
Description		syntaxin 1A	calcium voltage-gated channel subunit alpha1 D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Cell Junction Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Presynaptic Membrane Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Plasma Membrane Voltage-gated Calcium Channel Complex Z Disc Cochlear Hair Cell Ribbon Synapse Integral Component Of Presynaptic Active Zone Membrane L-type Voltage-gated Calcium Channel Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium Ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential	Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Adenylate Cyclase Activity Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Manidipine
Diseases
GWAS			Age at first sexual intercourse ( 27089180) Axial length ( 24144296) Blood protein levels ( 28240269) Body mass index ( 25673413) Diastolic blood pressure ( 29403010 25249183 30487518 30578418) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 29403010 25249183 30487518 30578418) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		60 interacting genes: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEC22B SEPTIN2 SEPTIN5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18	3 interacting genes: CALB1 FGFR2 STX1A
Entrez ID		6804	776
HPRD ID		01721	00247
Ensembl ID		ENSG00000106089	ENSG00000157388
Uniprot IDs		Q16623 Q75ME0	A0A1B0GUN6 Q01668 Q59GD8
PDB IDs			3LV3
Enriched GO Terms of Interacting Partners?
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