RIMS1 and CACNA1B

Number of citations of the paper that reports this interaction (PubMedID 11438518)
71

Data Source:
HPRD (in vitro)

		RIMS1	CACNA1B
Description		regulating synaptic membrane exocytosis 1	calcium voltage-gated channel subunit alpha1 B
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component	Plasma Membrane Voltage-gated Calcium Channel Complex Dendrite Neuronal Cell Body Presynapse
	Molecular Function	RNA Binding Protein Binding Rab GTPase Binding GTPase Regulator Activity Ion Channel Binding Metal Ion Binding	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Intracellular Protein Transport Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion Regulated Exocytosis Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Calcium Ion Transport Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Ion Transmembrane Transport Response To Pain Modulation Of Chemical Synaptic Transmission Membrane Depolarization Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation	Presynaptic depolarization and calcium channel opening
Drugs			Amlodipine Spironolactone Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Agmatine
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Weight ( 28552196)
Interacting Genes		15 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	9 interacting genes: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		22999	774
HPRD ID		09435	03005
Ensembl ID		ENSG00000079841	ENSG00000148408
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	Q00975
PDB IDs		2CSS	2LCM
Enriched GO Terms of Interacting Partners?
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