RPIA and ATPAF2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		RPIA	ATPAF2
Description		ribose 5-phosphate isomerase A	ATP synthase mitochondrial F1 complex assembly factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intracellular Membrane-bounded Organelle	Mitochondrion Cytosol Nuclear Speck
	Molecular Function	Ribose-5-phosphate Isomerase Activity Protein Binding Identical Protein Binding Monosaccharide Binding	Protein Binding
	Biological Process	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Ribose Phosphate Metabolic Process	Proton-transporting ATP Synthase Complex Assembly
Pathways		RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway
Drugs		4-phospho-L-threonic acid
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 30072576)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		14 interacting genes: ATPAF2 CENPP FOXP2 FXR2 GORASP2 LNX1 NIF3L1 NTAQ1 PCMT1 PTPN11 RNF208 STK16 TXN2 VTA1	24 interacting genes: APP ATP5F1A ATP5F1B BEGAIN CFAP206 DDIT3 EBF1 EWSR1 IKZF3 KRT40 LNX1 LRRFIP2 LZTS2 MAGEA6 PAK5 PKP4 PRDM14 RAD54B REL RPIA SORBS2 TP53BP2 TRIM23 TRIM27
Entrez ID		22934	91647
HPRD ID		01589	10599
Ensembl ID		ENSG00000153574	ENSG00000171953
Uniprot IDs		P49247	Q8N5M1
PDB IDs
Enriched GO Terms of Interacting Partners?
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