ARHGEF15 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ARHGEF15	LASP1
Description		Rho guanine nucleotide exchange factor 15	LIM and SH3 protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		9 interacting genes: C11orf49 CEP55 DNAJC5 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	40 interacting genes: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 COPS5 CRK DAZAP2 DNMT1 EHMT2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 RBPMS REL RHOXF2 SEPTIN3 SPRY2 STAT3 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 UHRF1 ZBTB9 ZC2HC1A ZYX
Entrez ID		22899	3927
HPRD ID		10535	04229
Ensembl ID		ENSG00000198844	ENSG00000002834
Uniprot IDs		A0A0S2Z547 O94989	A0A024R1S8 B4DIC4 Q14847
PDB IDs			3I35
Enriched GO Terms of Interacting Partners?
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