ARHGEF15 and ESRRG

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGEF15	ESRRG
Description		Rho guanine nucleotide exchange factor 15	estrogen related receptor gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite	Nuclear Chromatin Nucleoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Nuclear Receptor transcription pathway
Drugs			Troglitazone Diethylstilbestrol Tamoxifen Estradiol Cholic Acid Afimoxifene 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE 4-(1-methyl-1-phenylethyl)phenol 4,4'-PROPANE-2,2-DIYLDIPHENOL 4,4'-cyclohexane-1,1-diyldiphenol
Diseases
GWAS		Bipolar disorder ( 28115744) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to drug ( 30420678) Alcohol consumption ( 23743675) Breast cancer ( 29059683) Cardiac hypertrophy ( 21348951) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom (anhedonia) (ordinal trait) ( 31530331) Dialysis-related mortality ( 21546767) Energy expenditure (24h) ( 28476931) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) Major depressive disorder ( 23377640) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Optic nerve measurement (cup area) ( 20395239) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Sleep duration ( 25469926) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Weight ( 28552196)
Interacting Genes		9 interacting genes: C11orf49 CEP55 DNAJC5 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	32 interacting genes: APP ARHGEF15 CALM1 DAXX DEUP1 DUT EBP ESRRA HGS HIF1A KIFC3 LRRK2 MARK1 MEOX2 MFHAS1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PNRC1 PNRC2 PPARGC1A PPARGC1B PROX1 PSMC5 SHTN1 SP1 SRA1 SRPK1 SUMO1P1 TLE1
Entrez ID		22899	2104
HPRD ID		10535	04274
Ensembl ID		ENSG00000198844	ENSG00000196482
Uniprot IDs		A0A0S2Z547 O94989	B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs			1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67
Enriched GO Terms of Interacting Partners?
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