PHLDA1 and EIF3D

Number of citations of the paper that reports this interaction (PubMedID 11369516)
7

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PHLDA1	EIF3D
Description		pleckstrin homology like domain family A member 1	eukaryotic translation initiation factor 3 subunit D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cytoplasmic Vesicle	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding Phosphatidylinositol Phosphate Binding	RNA Binding Translation Initiation Factor Activity Protein Binding MRNA Cap Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Positive Regulation Of Apoptotic Process FasL Biosynthetic Process	Formation Of Cytoplasmic Translation Initiation Complex Cap-dependent Translational Initiation Translational Initiation Positive Regulation Of Translation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation Positive Regulation Of MRNA Binding
Pathways		Interaction between PHLDA1 and AURKA	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 30061737 29892015) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		10 interacting genes: APP EIF3D FBXO7 HSPA4 HSPA4L KRTAP4-12 MDFI PABPC4 PLSCR1 RPL14	13 interacting genes: BEND5 CREBBP DNAJB11 EIF3G EIF3J EIF3L EIF5 HOMER3 LZTS2 PHLDA1 REL SAT1 TRIM27
Entrez ID		22822	8664
HPRD ID		05625	04888
Ensembl ID		ENSG00000139289	ENSG00000100353
Uniprot IDs		Q8WV24	O15371
PDB IDs
Enriched GO Terms of Interacting Partners?
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