PHLDA1 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 17024176)
23

Data Source:
HPRD (in vivo, in vitro)

		PHLDA1	HSPA4
Description		pleckstrin homology like domain family A member 1	heat shock protein family A (Hsp70) member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cytoplasmic Vesicle	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol Phosphate Binding	Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Positive Regulation Of Apoptotic Process FasL Biosynthetic Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways		Interaction between PHLDA1 and AURKA	Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 30061737 29892015) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		10 interacting genes: APP EIF3D FBXO7 HSPA4 HSPA4L KRTAP4-12 MDFI PABPC4 PLSCR1 RPL14	65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A
Entrez ID		22822	3308
HPRD ID		05625	09025
Ensembl ID		ENSG00000139289	ENSG00000170606
Uniprot IDs		Q8WV24	P34932
PDB IDs
Enriched GO Terms of Interacting Partners?
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